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In vitro drug interaction studies have demonstrated that mitoxantrone did not inhibit CYP450 1A2, 2A6, 2C9, 2C19, 2D6, 2E1 and 3A4 throughout a wide focus array. The final results of in vitro induction experiments are inconclusive, but advise that mitoxantrone could be a weak inducer of CYP450 2E1 exercise. Pharmacokinetic research with the interac